The use of hydroxychloroquine in patients with a history of renal calculi requires caution due to potential effects on urinary pH and stone formation. plaqcmd.com hydroxychloroquine for lupus Hydroxychloroquine has been associated with nephrolithiasis, particularly in patients with underlying risk factors such as hypercalcemia or hyperuricosuria. Healthcare providers should assess urinary pH and monitor renal function regularly in patients receiving hydroxychloroquine therapy to prevent kidney stone formation.